{"id":55369,"date":"2013-07-24T09:28:08","date_gmt":"2013-07-24T00:28:08","guid":{"rendered":"http:\/\/musojuku.jp\/bifu-blog\/?p=55369"},"modified":"2013-07-24T12:06:13","modified_gmt":"2013-07-24T03:06:13","slug":"%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85%e3%81%af%e3%80%8c%ef%bc%93%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e3%80%8d","status":"publish","type":"post","link":"https:\/\/musojuku.jp\/bifu-blog\/?p=55369","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u300c\uff13\u578b\u7cd6\u5c3f\u75c5\u300d"},"content":{"rendered":"<p>\u30de\u30af\u30ed\u30d3\u30aa\u30c6\u30a3\u30c3\u30af\u3067\u306f\u3059\u3067\u306b\u72ec\u81ea\u306e\u898b\u89e3\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u3053\u3053\u3067\u306f<span style=\"line-height: 24px;\">\u79c1\u898b\u3092\u5165\u308c\u305a\u306b\u8a18\u4e8b\u306b\u3057\u307e\u3059\u3002<br \/>\n\u591a\u304f\u306e\u4eba\u304c\u8aad\u3081\u308b\u3088\u3046\u306b\u3001\u5143\u306e\u8a18\u4e8b\u3092\u8ee2\u8f09\u3057\u307e\u3059\u3002<br \/>\n<\/span><\/p>\n<p><span style=\"line-height: 24px;\">\u00a0<\/span><\/p>\n<h1><\/h1>\n<div>\n<h1>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u300c\uff13\u578b\u7cd6\u5c3f\u75c5\u300d<\/h1>\n<p><a href=\"http:\/\/apital.asahi.com\/article\/series.html?section=%E3%82%A2%E3%83%AB%E3%83%84%E3%83%8F%E3%82%A4%E3%83%9E%E3%83%BC%E7%97%85%E3%82%92%E6%B2%BB%E3%81%99%E8%96%AC%E3%81%B8%E3%81%AE%E9%81%93\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u6cbb\u3059\u85ac\u3078\u306e\u9053<\/a><\/p>\n<p><a href=\"http:\/\/apital.asahi.com\/keyword\/author.html?author=2012112200098\">\u7b20\u9593\u7766 \uff08\u304b\u3055\u307e\u30fb\u3042\u3064\u3057\uff09<\/a><\/p>\n<p>2013\u5e747\u6708 7\u65e5<\/p>\n<p>\u4e2d\u90e8\u5927\u5fdc\u7528\u751f\u7269\u5b66\u90e8\u306e\u6d25\u7530\u5b5d\u7bc4\u51c6\u6559\u6388\uff08\u98df\u54c1\u6a5f\u80fd\u5b66\uff09\u3089\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u30af\u30eb\u30af\u30df\u30f3\u306b\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3055\u305b\u308b\u30db\u30eb\u30e2\u30f3\uff08GLP-1\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u6fc3\u5ea6\u3092\u9ad8\u3081\u308b\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u6700\u8fd1\u7a81\u304d\u6b62\u3081\u3089\u308c\u307e\u3057\u305f\uff08\uff12\uff10\uff11\uff13\u5e74\uff15\u6708\uff12\uff14\u65e5\u4ed8\u4e2d\u65e5\u65b0\u805e\u793e\u4f1a\u9762\uff09\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u300c\uff13\u578b\u7cd6\u5c3f\u75c5\u300d\uff08\u30e1\u30e2\uff15\u53c2\u7167\uff09\u3068\u3082\u547c\u3070\u308c\u3066\u304a\u308a\u3001\u30af\u30eb\u30af\u30df\u30f3\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u306e\u95a2\u9023\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u6a5f\u5e8f\u306e\u89e3\u660e\u304c\u5f85\u3061\u671b\u307e\u308c\u308b\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n<\/div>\n<div>\n<p>\u3000\u6749\u672c\u516b\u90ce\u5148\u751f\u306f\u3001PE\uff18\uff15\uff19\u306f\u30ec\u30f3\u30d0\u30fc\u306e\u6539\u826f\u578b\u3060\u3068\u8ff0\u3079\u3066\u304a\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u7384\u7c73\u306b\u30ab\u30ec\u30fc\u3092\u304b\u3051\u3066\u98df\u3079\u308b\u3068\u3088\u308a\u52b9\u679c\u7684\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002\u7384\u7c73\u306e\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u8a8d\u77e5\u75c7\u4ecb\u8b77\u7814\u7a76\u30fb\u7814\u4fee\u6771\u4eac\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u90e8\u9577\u3067\u3042\u308a\u6d74\u98a8\u4f1a\u75c5\u9662\u8a3a\u7642\u90e8\u9577\u306e\u9808\u8c9d\u4f51\u4e00\u533b\u5e2b\u304c\u8457\u66f8\u306e\u4e2d\u3067\u8a00\u53ca\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u4e00\u90e8\u6539\u5909\u3057\u3066\u4ee5\u4e0b\u306b\u3054\u7d39\u4ecb\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<blockquote><p><em>\u3000\u300c\u7384\u7c73\u3092\u7cbe\u7c73\u3057\u305f\u767d\u7c73\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6804\u990a\u7d20\u304c\u542b\u307e\u308c\u305f\u7a2e\u76ae\u3084\u80da\u82bd\u306e\u90e8\u5206\u304c\u3042\u3089\u304b\u3058\u3081\u53d6\u308a\u9664\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u7a2e\u76ae\u3084\u80da\u82bd\u306b\u306f\u30d3\u30bf\u30df\u30f3B\uff11\u30fbB\uff12\u30fbB\uff16\u30fbE\u3001\u30d1\u30f3\u30c8\u30c6\u30f3\u9178\u3001\u30d5\u30a3\u30c1\u30f3\u9178\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3001\u8449\u9178\u306a\u3069\u306e\u8cb4\u91cd\u306a\u6804\u990a\u7d20\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u7384\u7c73\u306f\u305d\u308c\u3060\u3051\u3067\u5b8c\u5168\u98df\u54c1\u3067\u3042\u308b\u3068\u8a00\u308f\u308c\u308b\u307b\u3069\u3001\u6804\u990a\u7684\u306b\u512a\u308c\u305f\u98df\u3079\u7269\u306a\u306e\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u4e3b\u98df\u306b\u95a2\u3057\u3066\u306f\u767d\u7c73\u3067\u306f\u306a\u304f\u3053\u306e\u7384\u7c73\u3092\u98df\u3079\u308b\u3088\u3046\u306b\u3059\u308b\u3068\u3001\u30dc\u30b1\u4e88\u9632\u306e\u52b9\u679c\u3092\u898b\u8fbc\u3081\u307e\u3059\u3002\u300d\uff08\u9808\u8c9d\u4f51\u4e00\uff1a\u671d\u5915\uff11\uff15\u5206 \u6b7b\u306c\u307e\u3067\u30dc\u30b1\u306a\u3044\u982d\u3092\u3064\u304f\u308b\uff01 \u3059\u3070\u308b\u820e, \u6771\u4eac, 2012, p174\uff09<\/em><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<blockquote><p><em><strong>\u30e1\u30e2\uff15\uff1a\uff13\u578b\u7cd6\u5c3f\u75c5<\/strong><\/em><br \/>\n<em>\u3000\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u300c\uff13\u578b\u7cd6\u5c3f\u75c5\u300d\u3068\u8a00\u3063\u305f\u306e\u306f\u7c73\u30da\u30f3\u30b7\u30eb\u30d0\u30cb\u30a2\u5927\u5b66\u533b\u5b66\u90e8\u7cbe\u795e\u533b\u5b66\u30fb\u795e\u7d4c\u5b66\u306e\u30b9\u30c6\u30a3\u30fc\u30d6\u30f3\u30fb\u30a2\u30fc\u30ce\u30eb\u30c9\u6559\u6388\u3067\u3059\u3002\u30a2\u30fc\u30ce\u30eb\u30c9\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u7cd6\u5c3f\u75c5\u3067\u306f\u306a\u3044\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u306e\u6d77\u99ac\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u7cd6\u5c3f\u75c5\u3067\u306f\u306a\u3044\u306e\u306b\u8133\u5185\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u52b9\u304d\u304c\u60aa\u304f\u3001\u795e\u7d4c\u7d30\u80de\u304c\u30b0\u30eb\u30b3\u30fc\u30b9\uff08\u30d6\u30c9\u30a6\u7cd6\uff09\u3092\u4f7f\u3048\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u306e\u3067\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u300c\u8133\u306e\u7cd6\u5c3f\u75c5\u300d\u3068\u3044\u3063\u3066\u5dee\u3057\u652f\u3048\u306a\u3044\u72b6\u614b\u3067\u3057\u305f\uff08\u767d\u6fa4\u5353\u4e8c\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u306f\u300c\u7b2c\u4e09\u306e\u7cd6\u5c3f\u75c5\u300d. \u6587\u85dd\u6625\u79cb\u7b2c91\u5dfb\u7b2c\uff16\u53f7 pp304-306 2013\uff09\u3002<\/em><br \/>\n<em>\u3000\u9ad8\u8840\u7cd6\u306b\u306a\u308b\u3068\u7cd6\u304c\u975e\u7279\u7570\u7684\u304b\u3064\u975e\u9175\u7d20\u7684\u306b\u86cb\u767d\u306b\u7d50\u5408\u3057\u3001\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08advanced glycation endproduct\uff1bAGE\uff09\u3068\u306a\u308a\u307e\u3059\uff08\u91cc \u76f4\u884c\uff1a\u751f\u6d3b\u7fd2\u6163\u75c5\u3068\u8a8d\u77e5\u75c7\u2500\u7cd6\u5c3f\u75c5\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027. MEDICINAL Vol.2 No.9 64-70 2012\uff09\u3002RAGE\uff08receptor for AGE\uff09\u306f\u3001AGE\u306e\u53d7\u5bb9\u4f53\u3067\u3059\u3002<br \/>\n<\/em><\/p>\n<p><em>\u3000\u662d\u548c\u5927\u5b66\u6a2a\u6d5c\u5e02\u5317\u90e8\u75c5\u9662\u306e\u798f\u4e95\u4fca\u54c9\u51c6\u6559\u6388\uff08\u795e\u7d4c\u5185\u79d1\uff09\u304cRAGE\u963b\u5bb3\u85ac\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u306b\u95a2\u3057\u3066\u8a00\u53ca\u3057\u3066\u304a\u308a\u307e\u3059\uff08\u798f\u4e95\u4fca\u54c9\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u306e\u4eca\u6614\u7269\u8a9e. \u8a8d\u77e5\u795e\u7d4c\u79d1\u5b66 Vol.13 110-117 2011\uff09\u3002\u3061\u3087\u3063\u3068\u96e3\u89e3\u306a\u8a71\u306b\u306a\u308a\u307e\u3059\u304c\u8981\u70b9\u3092\u4ee5\u4e0b\u306b\u629c\u7c8b\u3057\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<br \/>\n<\/em><\/p>\n<p><em>\u3000RAGE\u306fAGE\u3068\u547c\u3070\u308c\u308b\u69cb\u9020\u4f53\u306b\u5bfe\u3059\u308b\u53d7\u5bb9\u4f53\u3067\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u306e\u69cb\u9020\u3092\u6709\u3057\u3001\u795e\u7d4c\u7d30\u80de\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff08\u30e1\u30e2\uff16\u53c2\u7167\uff09\u3001\u8840\u7ba1\u5185\u76ae\u306a\u3069\u306b\u767a\u73fe\u3057\u307e\u3059\u3002<br \/>\n<\/em><\/p>\n<p><em>\u3000RAGE\u304c\u8840\u7ba1\u58c1\u306b\u767a\u73fe\u3059\u308b\u3068\u3001\u8133\u8840\u7ba1\u95a2\u9580\u3092\u901a\u3057\u3066\u8840\u4e2d\u304b\u3089\u8133\u5185\u3078A\u03b2\u306e\u79fb\u9001\u3092\u4fc3\u9032\u3057\u8133\u5185A\u03b2\u6c88\u7740\u3092\u52a9\u9577\u3057\u307e\u3059\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u767a\u73fe\u3059\u308bRAGE\u306f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08cytokine\uff09\u306a\u3069\u306e\u708e\u75c7\u60f9\u8d77\u7269\u8cea\u3092\u8a98\u5c0e\u3057\u3066\u3001AD\u75c5\u7406\u306e\u7279\u5fb4\u3067\u3042\u308b\u5c40\u6240\u8133\u5185\u708e\u75c7\u3092\u751f\u3058\u307e\u3059\u3002<\/em><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<blockquote><p><em><strong>\u30e1\u30e2\uff16\uff1a\u30df\u30af\u30ed\u30b0\u30ea\u30a2<\/strong><\/em><br \/>\n<em>\u3000\u300c\u795e\u7d4c\u7d30\u80de\u304c\u6b7b\u3093\u3060\u308a\u3001\u5f31\u307e\u3063\u305f\u308a\u3059\u308b\u3068\u300e\u6383\u9664\u5c4b\u7d30\u80de\u300f\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u7570\u5e38\u306a\u307e\u3067\u306b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u3092\u653e\u51fa\u3059\u308b\u3002\u904e\u5270\u306a\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306f\u795e\u7d4c\u7d30\u80de\u3092\u50b7\u3064\u3051\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084ALS\u306e\u539f\u56e0\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u3002\u300d\uff082011\u5e74\uff16\u670822\u65e5\u4ed8\u671d\u65e5\u65b0\u805e\u793e\u4f1a\u9762\uff09<\/em><\/p>\n<p>&nbsp;<\/p><\/blockquote>\n<p><em>\uff08\u3064\u3065\u304f\uff09<\/em><\/p>\n<\/div>\n<p><em><span style=\"line-height: 24px;\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/musojuku.jp\/bifu-blog\/wp-content\/uploads\/2013\/07\/IMG_2535.jpg\" alt=\"IMG_2535\" width=\"550\" 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